| Sl No | API Bulk Drugs | Reaction Type | Recommended Catalyst | Catalyst Type Code |
|---|
1
| Aceclofenac
| O-Debenzylation
| 10% Pd on Carbon
| S39A
|
2
| Aliskiren
| Azide to Amine
| 5% Pd on Carbon
| S58B
|
3
| Almotriptan
| Heck Coupling
| Pd(OAc)2
| NA
|
4
| Amlodipine Besylate
| Reduction of Azide to Amine
| 5% Pd on Calcium Carbonate
| S21C
|
5
| Amphetamine
| Nitro Reduction
| 10% Pd on Carbon
| S487B
|
6
| Aprepitant
| N-Debenzylation/Keto Hydrogenation
| 10% Pd on Carbon
| S90A
|
7
| Atorvastatin
| Nitrile to Amine
| 5% Pd on Carbon
| S58B
|
8
| Azithromycin
| lmine to Amine
| 5% Pt on Carbon
| S18MA
|
9
| Benazepril HCI
| Keto to Alcohol
| 5% Pt on Carbon
| S117C
|
10
| Atorvastatin
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
11
| Carvedilol
| O-Debenzylation
| 10% Pd on Carbon
| S39A
|
12
| Cilazapril
| O-Debenzylation
| 10% Pd on Carbon
| S90A
|
13
| Cisapride
| Hydrogenation of tetrahydropyridine
| 10% Pd on Carbon
| S487B
|
14
| Darunavir
| Nitro to Amine
| 5% Pd on Carbon
| S487B
|
15
| Delavirdin Mesylate
| Reductive Amination
| 5% Pd on Carbon
| S487B
|
16
| Didanosine
| Double Bond Reduction
| 5% Pd on Carbon
| S487B
|
17
| Dobutamine HCI
| Reductive Alkylation
| 3% Pt on Carbon
| S155B
|
18
| Dobutamine HCI
| Double bond/Pyrimidine Ring Reduction
| 3% Pt on Carbon
| S117C
|
19
| Duloxetine
| Keto Group Reduction
| 5% Pt on Carbon
| S18MA
|
20
| Efavirenz
| Debenzylation
| 5% Pd on Carbon
| S39A
|
21
| Eletriptan
| Conjugate Bond Hydrogenolysis
| 5% Pd on Carbon
| S487B
|
22
| Emtricitabine
| Selective Oxidation
| Pd(OAc)2
| NA
|
23
| Enalapril Maleate
| Reductive Condensation
| 5% Pt on Carbon
| S90A
|
24
| Eprosartan
| Dehalogenation
| 10% Pd on Carbon
| S90A
|
25
| Escitaloparm
| Dehalogenation
| 10% Pd on Carbon
| S90A
|
26
| Ezetimibe
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
27
| Fexofenadine
| Suzuki Coupling
| Pd(PPh3)4
| NA
|
28
| Fluoxetine HCI
| Asymmetric Hydrogenation
| Rh(COD)Cl2
| NA
|
29
| Formeterol
| Debenzylation/Nitroreduction
| 5% Pd on Carbon
| S39AS487B
|
30
| Fosamprenavir Calcium
| Nitro to Amine
| 5% Pd on Carbon/58
| S487B
|
31
| Fosfluconazole
| O-Debenzylation
| 5% Pd on Carbon
| S90A
|
32
| Fosinopril Sodium
| Debenzylation
| 5% Pd on Carbon
| S39A
|
33
| Frovatriptan
| Keto Group Reduction
| 5% Pt on Carbon
| S117C
|
34
| Gabapentin
| Oxime to Amine
| 5% Rh on Alumina
| S525A
|
35
| Galantamine
| Asymmetric Hydrogenation
| Chiral Catalyst
| NA
|
36
| Gemifloaxacin
| Double bond/Nitrile Reduction
| 5% Pd on Carbon
| S58B
|
37
| Gluconoic Acid
| Oxidation
| 4% Pd+1%Pt+5% Bi on Carbon
| S430
|
38
| lbandronate Sodium
| Debenzylation
| 20% Pd(OH)2 on Carbon
| S91A
|
39
| Imatinib Mesylate
| Nitro to Amine
| 5% Pd on Carbon
| S487B
|
40
| lmipenem
| Debenzylation
| 20% Pd(OH)2 on Carbon
| S91A
|
41
| lndianvir
| Pyridine Ring Reduction
| 5% Rh on Alumina
| S525A
|
42
| Irbesatan
| N-Debenzylation
| 5% Pd on Carbon
| S39A
|
43
| lrinotecan HCI
| Keto reduction,Debenzylation,Endocyclic Bond Saturation
| 5% Pt on Carbon,5% Pd on Carbon
| S117C,S39A
|
44
| Itraconazole
| Nitro Reduction
| 5% Pd on Carbon
| S487B
|
45
| L-Alaninol
| Keto to Alcohol
| 5% Ru on Carbon
| S19A
|
46
| Lamivudine
| Debenzylation
| 5% Pd on Carbon
| S39A
|
47
| Lansoprazole
| Nitrile Reduction
| 5% Pd on Carbon
| S58B
|
48
| Latanoprost
| Saturation of C=C Bond
| 5% Pd on Carbon
| S487B
|
49
| Letrozole
| Reduction of Hydrazone Group
| 10 % Pd on Carbon
| S487B
|
50
| Levofloaxacin
| Hydrogenation of Nitro Group
| 10% Pd on Carbon
| S487B
|
51
| Lisinopril
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
52
| Lopinavir
| N- Debenzylation & Saturation of conjugate bond
| 10% Pd on Carbon
| S90A
|
53
| Loratadine
| Coupling
| Pd(OAc)2
| NA
|
54
| Losartan Potassium
| HeckCoupling
| Pd(OAc)2
| NA
|
55
| Meropenem
| N-Debenzylation
| 10% Pd on Carbon
| S39A
|
56
| Methyl Penidate
| Pyrimidine Ring Reduction
| 5% Rh on Carbon
| S20A
|
57
| Milnacipran
| Reduction of Azide
| 10% Pd on Carbon
| S90A
|
58
| Minocycline
| Reductive Demethylation
| 3% Pt on Carbon
| S155B
|
59
| Montelucast Sodium
| Cross Coupling
| Pd(OAc)2
| NA
|
60
| Moxifloaxacin
| Pyridyl Ring Reduction
| 5% Rh on Carbon
| S20A
|
61
| Nabumentone
| Exocyclic Triple Bond Reduction
| 5% Pd on Carbon
| S487B
|
62
| Naratriptan
| N-Debenzylation/Double Bond Reduction
| 5% Pd on Carbon
| S39AS487B
|
63
| Nebivolol
| N-Debenzylation
| 10% Pd on Carbon
| S90A
|
64
| Nevirapine
| Pyridine Ring Reduction
| 5% Rh on Carbon
| S20A
|
65
| Olanzapine
| N-Debenzylation
| 10% Pd on Carbon
| S39A
|
66
| Omeprazole
| Nitrile Reduction
| 5% Pd on Carbon
| S58B
|
67
| Orlistat
| O-Debenzylation
| 20% Pd(OH)2 on Carbon
| S91A
|
68
| Oseltamivir
| Deallylation
| 10% Pd on Carbon
| S487B
|
69
| Paclitaxel
| Deprotection of Benzyl Group
| 20% Pd(OH)2 on Carbon
| S91A
|
70
| Paliperidone
| Debenzylation
| 5% Pd on Carbon
| S39A
|
71
| Pantoprazole
| Nitro to Amine
| 5% Pd on Carbon
| S487B
|
72
| Paroxitine HCI
| Debenzylation
| 20% Pd(OH)2 on Carbon
| S91A
|
73
| Perindopril
| O-Debenzylation
| 10%Pd/C
| S39A
|
74
| Picotamide
| Partial Pyridine Ring Reduction
| 5% Rh/C,5% Pt/C
| S20A,CSR1
|
75
| Pioglitazone
| Conjugate Double Bond Reduction
| 5% Pd on Carbon
| S487B
|
76
| Pitavastatin
| Cross Coupling
| Allyl Palladium Chloride
| NA
|
77
| Pregabalin
| O-Debenzylation/Nitrile Reduction
| 5% Pd on Carbon
| S39A
|
78
| Quetiapine
| Nitro Group Reduction
| 10% Pd on Carbon
| S487B
|
79
| Quinapril
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
80
| Rabeprazole
| Nitrile to Amine
| 5% Pd on Carbon
| S58B
|
81
| Ramipril
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
82
| Risperidone
| Pyrimidine Ring Reduction
| 5% Rh on Carbon
| S20A
|
83
| Rizatriptan
| Nitro to Amine
| 10% Pd on Carbon
| S487B
|
84
| Ropinirole
| Nitro to Indole
| 5% Pd on Carbon
| S487B
|
85
| Rosiglitazone
| Conjugate double bond Reduction
| 10% Pd on Carbon
| S90A
|
86
| Rosuvastatin
| O-Debenzylation
| 20% Pd(OH)2 on Carbon
| S91A
|
87
| Salbutamol
| Debenzylation
| 5% Pd on Carbon
| S39A
|
88
| Salmaterol
| Debenzylation
| 5% Pd on Carbon
| S39A
|
89
| Sertaline HCI
| Keto Group Hydrogenation
| 5% Pd on Calcium Carbonate
| S21C
|
90
| Sitagliptin
| Conjugate Double bond reduction
| 5% Pd on Carbon
| S487B
|
91
| Sumatriptan
| Nitro Reduction
| 5% Pd on Carbon
| S487B
|
92
| Tadalafil
| Oxime to Amine
| 5% Pt on Carbon
| S18MA
|
93
| Tandolapril
| Debenzylation
| 20% Pd(OH)2 on Carbon
| S39A
|
94
| Tazobactum
| Dehalogenation
| 2.5% Pd on Carbon
| S487B
|
95
| Telmisartan
| Nitro to amine
| 10% Pd on Carbon
| S487B
|
96
| Theophylline
| Nitro Reduction
| 5% Pd on Carbon
| S487B
|
97
| Torpiramate
| Hydrogenation of Azide
| 10% Pd on Carbon
| S90A
|
98
| Tramadol HCI
| Debenzylation
| 5% Pd on Carbon
| S39A
|
99
| Trimetazidine
| Reductive Amination
| 3% Pt on Carbon
| S155B
|
100
| Valacyclovir HCI
| Debenzylation
| 5% Pd on Carbon
| S39A
|
101
| Valdecoxib
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
102
| Valsartan
| O-Debenzylation
| 5% Pd on Carbon
| S39A
|
103
| Vardenafil
| Conjugate bond Hydrogenolysis
| 5% Pd on Carbon
| S487B
|
104
| Venlafaxine
| Reduction of Nitrile
| 5% Pd on Carbon
| S58B
|
105
| Verapamil
| Keto to Alcohol
| 20%Pd(OH)2 on Carbon,PdCI,
| S91A
|
106
| Zanamivir
| Hydrogenation of Azide
| 10% Pd on Carbon
| S90A
|
107
| Zidovudine
| Debenzylation
| 5%Pd on Carbon
| S39A
|
108
| Ziprasidone
| Dehalogenation
| 10%Pd on Carbon
| S90A
|
109
| Zolmitriptan
| Nitro to Amine
| 5%Pd on Carbon
| S487B
|
110
| Zolpidem
| Dechlorination
| 10%Pd on Carbon
| S90A
|