Catalyst Application Table
Sl NoAPI Bulk DrugsReaction TypeRecommended CatalystCatalyst Type Code

1

Aceclofenac

O-Debenzylation

10% Pd on Carbon

S39A

2

Aliskiren

Azide to Amine

5% Pd on Carbon

S58B

3

Almotriptan

Heck Coupling

Pd(OAc)2

NA

4

Amlodipine Besylate

Reduction of Azide to Amine

5% Pd on Calcium Carbonate

S21C

5

Amphetamine

Nitro Reduction

10% Pd on Carbon

S487B

6

Aprepitant

N-Debenzylation/Keto Hydrogenation

10% Pd on Carbon

S90A

7

Atorvastatin

Nitrile to Amine

5% Pd on Carbon

S58B

8

Azithromycin

lmine to Amine

5% Pt on Carbon

S18MA

9

Benazepril HCI

Keto to Alcohol

5% Pt on Carbon

S117C

10

Atorvastatin

O-Debenzylation

5% Pd on Carbon

S39A

11

Carvedilol

O-Debenzylation

10% Pd on Carbon

S39A

12

Cilazapril

O-Debenzylation

10% Pd on Carbon

S90A

13

Cisapride

Hydrogenation of tetrahydropyridine

10% Pd on Carbon

S487B

14

Darunavir

Nitro to Amine

5% Pd on Carbon

S487B

15

Delavirdin Mesylate

Reductive Amination

5% Pd on Carbon

S487B

16

Didanosine

Double Bond Reduction

5% Pd on Carbon

S487B

17

Dobutamine HCI

Reductive Alkylation

3% Pt on Carbon

S155B

18

Dobutamine HCI

Double bond/Pyrimidine Ring Reduction

3% Pt on Carbon

S117C

19

Duloxetine

Keto Group Reduction

5% Pt on Carbon

S18MA

20

Efavirenz

Debenzylation

5% Pd on Carbon

S39A

21

Eletriptan

Conjugate Bond Hydrogenolysis

5% Pd on Carbon

S487B

22

Emtricitabine

Selective Oxidation

Pd(OAc)2

NA

23

Enalapril Maleate

Reductive Condensation

5% Pt on Carbon

S90A

24

Eprosartan

Dehalogenation

10% Pd on Carbon

S90A

25

Escitaloparm

Dehalogenation

10% Pd on Carbon

S90A

26

Ezetimibe

O-Debenzylation

5% Pd on Carbon

S39A

27

Fexofenadine

Suzuki Coupling

Pd(PPh3)4

NA

28

Fluoxetine HCI

Asymmetric Hydrogenation

Rh(COD)Cl2

NA

29

Formeterol

Debenzylation/Nitroreduction

5% Pd on Carbon

S39AS487B

30

Fosamprenavir Calcium

Nitro to Amine

5% Pd on Carbon/58

S487B

31

Fosfluconazole

O-Debenzylation

5% Pd on Carbon

S90A

32

Fosinopril Sodium

Debenzylation

5% Pd on Carbon

S39A

33

Frovatriptan

Keto Group Reduction

5% Pt on Carbon

S117C

34

Gabapentin

Oxime to Amine

5% Rh on Alumina

S525A

35

Galantamine

Asymmetric Hydrogenation

Chiral Catalyst

NA

36

Gemifloaxacin

Double bond/Nitrile Reduction

5% Pd on Carbon

S58B

37

Gluconoic Acid

Oxidation

4% Pd+1%Pt+5% Bi on Carbon

S430

38

lbandronate Sodium

Debenzylation

20% Pd(OH)2 on Carbon

S91A

39

Imatinib Mesylate

Nitro to Amine

5% Pd on Carbon

S487B

40

lmipenem

Debenzylation

20% Pd(OH)2 on Carbon

S91A

41

lndianvir

Pyridine Ring Reduction

5% Rh on Alumina

S525A

42

Irbesatan

N-Debenzylation

5% Pd on Carbon

S39A

43

lrinotecan HCI

Keto reduction,Debenzylation,Endocyclic Bond Saturation

5% Pt on Carbon,5% Pd on Carbon

S117C,S39A

44

Itraconazole

Nitro Reduction

5% Pd on Carbon

S487B

45

L-Alaninol

Keto to Alcohol

5% Ru on Carbon

S19A

46

Lamivudine

Debenzylation

5% Pd on Carbon

S39A

47

Lansoprazole

Nitrile Reduction

5% Pd on Carbon

S58B

48

Latanoprost

Saturation of C=C Bond

5% Pd on Carbon

S487B

49

Letrozole

Reduction of Hydrazone Group

10 % Pd on Carbon

S487B

50

Levofloaxacin

Hydrogenation of Nitro Group

10% Pd on Carbon

S487B

51

Lisinopril

O-Debenzylation

5% Pd on Carbon

S39A

52

Lopinavir

N- Debenzylation & Saturation of conjugate bond

10% Pd on Carbon

S90A

53

Loratadine

Coupling

Pd(OAc)2

NA

54

Losartan Potassium

HeckCoupling

Pd(OAc)2

NA

55

Meropenem

N-Debenzylation

10% Pd on Carbon

S39A

56

Methyl Penidate

Pyrimidine Ring Reduction

5% Rh on Carbon

S20A

57

Milnacipran

Reduction of Azide

10% Pd on Carbon

S90A

58

Minocycline

Reductive Demethylation

3% Pt on Carbon

S155B

59

Montelucast Sodium

Cross Coupling

Pd(OAc)2

NA

60

Moxifloaxacin

Pyridyl Ring Reduction

5% Rh on Carbon

S20A

61

Nabumentone

Exocyclic Triple Bond Reduction

5% Pd on Carbon

S487B

62

Naratriptan

N-Debenzylation/Double Bond Reduction

5% Pd on Carbon

S39AS487B

63

Nebivolol

N-Debenzylation

10% Pd on Carbon

S90A

64

Nevirapine

Pyridine Ring Reduction

5% Rh on Carbon

S20A

65

Olanzapine

N-Debenzylation

10% Pd on Carbon

S39A

66

Omeprazole

Nitrile Reduction

5% Pd on Carbon

S58B

67

Orlistat

O-Debenzylation

20% Pd(OH)2 on Carbon

S91A

68

Oseltamivir

Deallylation

10% Pd on Carbon

S487B

69

Paclitaxel

Deprotection of Benzyl Group

20% Pd(OH)2 on Carbon

S91A

70

Paliperidone

Debenzylation

5% Pd on Carbon

S39A

71

Pantoprazole 

Nitro to Amine

5% Pd on Carbon

S487B

72

Paroxitine HCI

Debenzylation

20% Pd(OH)2 on Carbon

S91A

73

Perindopril

O-Debenzylation

10%Pd/C

S39A

74

Picotamide

Partial Pyridine Ring Reduction

5% Rh/C,5% Pt/C

S20A,CSR1

75

Pioglitazone

Conjugate Double Bond Reduction

5% Pd on Carbon

S487B

76

Pitavastatin

Cross Coupling

Allyl Palladium Chloride

NA

77

Pregabalin

O-Debenzylation/Nitrile Reduction

5% Pd on Carbon

S39A

78

Quetiapine

Nitro Group Reduction

10% Pd on Carbon

S487B

79

Quinapril

O-Debenzylation

5% Pd on Carbon

S39A

80

Rabeprazole

Nitrile to Amine

5% Pd on Carbon

S58B

81

Ramipril

O-Debenzylation

5% Pd on Carbon

S39A

82

Risperidone

Pyrimidine Ring Reduction

5% Rh on Carbon

S20A

83

Rizatriptan

Nitro to Amine

10% Pd on Carbon

S487B

84

Ropinirole

Nitro to Indole

5% Pd on Carbon

S487B

85

Rosiglitazone

Conjugate double bond Reduction

10% Pd on Carbon

S90A

86

Rosuvastatin

O-Debenzylation

20% Pd(OH)2 on Carbon

S91A

87

Salbutamol

Debenzylation

5% Pd on Carbon

S39A

88

Salmaterol

Debenzylation

5% Pd on Carbon

S39A

89

Sertaline HCI

Keto Group Hydrogenation

5% Pd on Calcium Carbonate

S21C

90

Sitagliptin

Conjugate Double bond reduction

5% Pd on Carbon

S487B

91

Sumatriptan

Nitro Reduction

5% Pd on Carbon

S487B

92

Tadalafil

Oxime to Amine

5% Pt on Carbon

S18MA

93

Tandolapril

Debenzylation

20% Pd(OH)2 on Carbon

S39A

94

Tazobactum

Dehalogenation

2.5% Pd on Carbon

S487B

95

Telmisartan

Nitro to amine

10% Pd on Carbon

S487B

96

Theophylline

Nitro Reduction

5% Pd on Carbon

S487B

97

Torpiramate

Hydrogenation of Azide

10% Pd on Carbon

S90A

98

Tramadol HCI

Debenzylation

5% Pd on Carbon

S39A

99

Trimetazidine

Reductive Amination

3% Pt on Carbon

S155B

100

Valacyclovir HCI

Debenzylation

5% Pd on Carbon

S39A

101

Valdecoxib

O-Debenzylation

5% Pd on Carbon

S39A

102

Valsartan

O-Debenzylation

5% Pd on Carbon

S39A

103

Vardenafil

Conjugate bond Hydrogenolysis

5% Pd on Carbon

S487B

104

Venlafaxine

Reduction of Nitrile

5% Pd on Carbon

S58B

105

Verapamil

Keto to Alcohol

20%Pd(OH)2 on Carbon,PdCI,

S91A

106

Zanamivir

Hydrogenation of Azide

10% Pd on Carbon

S90A

107

Zidovudine

Debenzylation

5%Pd on Carbon

S39A

108

Ziprasidone

Dehalogenation

10%Pd on Carbon

S90A

109

Zolmitriptan

Nitro to Amine

5%Pd on Carbon

S487B

110

Zolpidem

Dechlorination

10%Pd on Carbon

S90A